
Dormant season, and do the structural work early, because sycamore grows fast and stacks a lot of weight far out on long horizontal limbs before anyone thinks to address it. The trap is the anthracnose reaction — a cool wet Indiana spring strips the tree, the homeowner panics and asks for it to be 'cleaned out,' and heavily thinning a stressed tree that is trying to refoliate is the worst possible move; let it releaf and prune the following winter.
Sycamore anthracnose is the single most common misdiagnosis on this species. A cool wet spring — average daily temperatures below roughly 55°F at leaf-out — produces shoot blight, angular brown lesions following the leaf veins, and near-total early defoliation that looks fatal, but the tree refoliates by early summer and is fine. Real decline is a crown that never refills after midsummer, dieback progressing across consecutive years, and cankering or bleeding on the trunk; repeated hard anthracnose years also leave a permanently gnarled twiggy branch structure from all the killed shoot tips.