
Sycamore anthracnose is the single most common misdiagnosis on this species. A cool wet spring — average daily temperatures below roughly 55°F at leaf-out — produces shoot blight, angular brown lesions following the leaf veins, and near-total early defoliation that looks fatal, but the tree refoliates by early summer and is fine. Real decline is a crown that never refills after midsummer, dieback progressing across consecutive years, and cankering or bleeding on the trunk; repeated hard anthracnose years also leave a permanently gnarled twiggy branch structure from all the killed shoot tips.
It is the largest thing in almost any yard it occupies, and the one where entirely normal behavior generates the most wasted service calls — the peeling white, tan and gray bark that people report as disease is simply how the tree grows. What actually matters is scale: this is one of the most massive hardwoods in eastern North America, and it was routinely planted twenty feet from houses in the 1960s and 70s.