
The killer to rule out is persimmon wilt (Acremonium diospyri) — abrupt branch or whole-crown wilt with black streaking visible in the sapwood — though it is far more common in the Southeast than in Indiana. Here a persimmon going backward usually means fill dirt over the root flare or mower and trimmer damage to that thin blocky bark; stress reads as small leaves and light fruit set, dying reads as twigs that never break bud in May.
American persimmon gets removed in central Indiana for essentially one reason: a female tree dropping soft orange fruit onto a driveway, deck, patio or dog run from September into November. The species is dioecious and sex isn't visible until it fruits at around ten years old, so homeowners inherit the problem rather than choose it.