
One limb yellowing and wilting out of season while the rest of the canopy looks fine is the Thyronectria pattern — cut the bark on that limb and look for a sunken canker with reddish-brown discolored wood underneath. Whole-canopy thinning by August is usually mimosa webworm defoliation instead, and that tree will releaf next spring; the cankered one loses another limb every year until it is girdled.
This became the default replacement tree after emerald ash borer cleared the ash, and central Indiana now has street after street of it — which is the problem. Extension pathologists have warned for decades that honeylocust's pest and disease list turned serious precisely because it was overplanted, and a monoculture block moves mimosa webworm, mites, and canker through in a hurry.